I kind of went that route with The Wannabe Pirates and Greyhawk and the Starbucklers, Paul. The original sites were built ontop of Wordpress, using the comicpress plug-in. I did my advertising through Project Wonderful instead of Google Adwords, but the results were pretty much the same. Small page views equal small advertising returns.
Add into it they were mostly images (the comics themselves) and I found that I needed to go back and transcribe every strip in order to show up in search engines. I worried over it for awhile, using tools in Google Adsense to find keywords and terms to try to improve things, but the bottom line is you gotta' have lots of eyes on your page to make that model work and my stuff wasn't attracting them.
I tell you one thing that is frustrating, YouTube won't put ads on my Stalled Trek video because they don't believe I own the material. It's not so much the money, since it hasn't garnered that many views, it's that they are in a sense, accusing me of wrong-doing. I suppose I could try to push the matter with them, but it hasn't seemed like a high priority.
Instead of the comic strips, how about a true blog, posting articles/discussions on the creation, writing, whatever. Place adwords on those posts. On youtube, build a channel that links back to the blog, that way you drive traffic/pageviews. The comics can create a following, the blog entries generate the revenue. Create a facebook page for it, google+ authorship, etc. It's not easy or quick, but it can work.