Hi friends ....
a customer asked me to produce an animation showing ( cartoon ) what happens in the brain when there is ingestion of ayahuasca.

Title "Hoasca Principios Ativos"
Dur 4'05"
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Wikipedia -

Chemistry

Harmine compounds are of beta-carboline origin. The three most studied beta-carboline compounds found in the B. caapi vine are harmine, harmaline and tetrahydroharmine. Harmine and harmaline are selective and reversible inhibitors of MAO-A, while tetrahydroharmine is a weak serotonin uptake inhibitor. This inhibition of MAO-A allows DMT to diffuse unmetabolized past the membranes in the stomach and small intestine and eventually get through the blood-brain barrier to activate receptor sites in the brain. Without the MAOI of MAO-A, DMT would be metabolized in the digestive tract and would not have an effect when taken orally
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I used the characters from TWO and all credits will be post in the credits ....
I had to hide the costumer's logo.
Presenting:
The girl as DMT
The witch as MAO-A
The guy as beta-carboline

The copy, transmission and/or reproduction ( outside Hash's servers ) of this video is expressly prohibited.

Very cool, Marcos!

overall very nicly done.
I personally like the psychedelic effects towards the end.
How are they done?

There are some weaknesses within the charaanimations.
I believe you could get away with it with faster cuts here and there.
It`s a bit lengthty for a commercial anyway.

thanks David, Jost...

Jost... the 'psychedelic effects' was done in Apophysis ... the animation isn't produced for a commercial.
thank you for comments

WOW

Brilliant absalutely brilliant,A great way of telling it

Very interesting, Marcos!

thank you fellows .....

I just watched it. Very cool Marcos I had a group of friends when I lived in Santa Fe, NM who studied with a fellow from South America somewhere. Every couple of months they would have an ayahuasca ceremony. I never took it, but they were all nice people and possessed a very strong reverence for the whole thing.